Riminophenazines with 2-(heteroaryl)amino substituents and their anti-microbial activity

US8716292B2 · kind B2 · utility

Assignee

• The Global Alliance for TB Drug Development, Inc. · US

Inventors

• Kai Liu · Beijing, CN
• Christopher B. Cooper · Lawrenceville, US
• Haihong Huang · New York, US
• Chun Li · Beijing, CN
• Binna Liu · Beijing, CN
• Yang Liu · Columbus, US
• Zhenkun Ma · Westfield, US
• Jingbin Wang · Beijing, CN
• Dali Yin · Beijing, CN
• Dongfeng Zhang · Nanhu, CN
• Gang Zhang · Beijing, CN
• Hao Zhang · Montgomery, US

Key dates

• Filing date: Jun 28, 2011
• Grant date: May 6, 2014
• Expiry date: Jun 28, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C09B55/009
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to riminophenazines having heteroaromatic substitutions, including those with 2-heteroaryl-amino substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments. A general representation of the 2-(heteroaryl)amino-riminophenazines is shown below.