Fluoroquinolone derivatives or sulfonamide moiety-containing compounds as inhibitors of tyrosyl-dnaphosphodiesterase (TDP1)
US8716295B2 · kind B2 · utility
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11Claims
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Inventors
Key dates
| Filing date | Oct 27, 2011 |
| Grant date | May 6, 2014 |
| Priority date | — |
| Expiry date | Oct 27, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y301/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for treating cancer in a subject, comprising administering to a subject having cancer a therapeutically effective amount of (i) a fluoroquinolone derivative that inhibits tyrosyl-DNA-phosphodiesterase 1 (Tdp1) activity or (ii) a sulfonamide moiety-containing compound that inhibits tyrosyl-DNA-phosphodiesterase 1 (Tdp1) activity, thereby treating the cancer in the subject. In certain embodiments, the fluoroquinolone derivative or sulfonamide moiety-containing compound is co-administered with a topoisomerase I (TopI) inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.