Patent · US Active

Multicomponent crystalline system of rosuvastatin calcium salt and vanillin

US8716305B2 · kind B2 · utility

3Cited by

3References

10Claims

0Family size

Assignee

BASF SE

Inventors

Andreas Hafner · Gelterkinden, CH
Fritz Blatter · Reinach, CH
Martin Szelagiewicz · Münchenstein, CH
Bernd Siebenhaar · Kandern, DE

Key dates

Filing date	Apr 16, 2012
Grant date	May 6, 2014
Priority date	—
Expiry date	Apr 16, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D239/42
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A novel solid form of Rosuvastatin comprises as the active ingredient a salt of bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)-amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid] and vanillin or vanillin derivatives. The crystal comprising the two components, and minor amounts of water, shows improved properties such as crystallization behavior stability and decreased hydroscopic behavior.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.