Sulfonamides with heterocycle and oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals

US8716317B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Stefanie Keil · Frankfurt am Main, DE
• Matthias Urmann · Eschborn, DE
• Wolfgang Wendler · Bad Camberg, DE
• Maike Glien · Frankfurt am Main, DE
• Hans Matter · Langenselbold, DE
• Harry R. Munson, Jr. · Durham, US

Key dates

• Filing date: May 22, 2009
• Grant date: May 6, 2014
• Expiry date: Oct 17, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to Sulfonamides with heterocycle and oxadiazolone headgroup and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta or PPARdelta and PPARalpha agonist activity. What is described are compounds of the formula (I), in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.