Pseudomonas AVR and HOP proteins, their encoding nucleic acids, and use thereof

US8716460B2 · kind B2 · utility

Assignees

• Kansas State University Research Foundation · US
• BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · US
• Cornell Research Foundation, Inc. · US
• The United States of America, as represented by the Secretary of Agriculture · US

Inventors

• James R. Alfano · Lincoln, US
• Alan Collmer · Ithaca, US
• Samuel W. Cartinhour · Ithaca, US
• David J. Schneider · Morganfield, US
• Xiaoyan Tang · Hefei, CN

Key dates

• Filing date: Dec 27, 2006
• Grant date: May 6, 2014
• Expiry date: Jul 27, 2029

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A40/146
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

One aspect of the present invention relates to isolated nucleic acid molecules encoding avirulence proteins or polypeptides of Pseudomonas syringae pv. syringae DC 3000, or nucleic acid molecules which are complementary thereto. Expression vectors, host cells, and transgenic plants which include the DNA molecules of the present invention are also disclosed. Another aspect relates to the isolated proteins or polypeptides and compositions containing the same. The various nucleic acid molecules and proteins of the present invention can be used to impart disease resistance to a plant, make a plant hypersusceptible to colonization by nonpathogenic bacteria, modify a metabolic pathway in a cell, cause eukaryotic cell death and treat a cancerous condition, as well as inhibit programmed cell death.