Methods and devices for nucleic acid synthesis
US8716467B2 · kind B2 · utility
82Cited by
20References
13Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 2, 2011 |
| Grant date | May 6, 2014 |
| Priority date | — |
| Expiry date | May 12, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/1068
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed are devices and methods to synthesize polynucleotides and libraries of polynucleotides such as libraries of oligonucleotides. In exemplary embodiments, the device includes a support having a plurality of features. Each feature contains a plurality of oligonucleotides. Within each feature, each of the plurality of oligonucleotides includes an identical predetermined subunit sequence of X nucleosides and a degenerate sequence of Y nucleosides. A predetermined combination of a subset of the features can be used to produce a polynucleotide having a predetermined sequence of Z nucleosides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.