Substituted benzotriazines and quinoxalines as inhibitors of P7OS6 kinase
US8716473B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 26, 2010 |
| Grant date | May 6, 2014 |
| Priority date | — |
| Expiry date | Jan 8, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides compounds of the formula (1):or salts or tautomers thereof; wherein X1 is N or N+(O−); X2 is N or CH; Q is a C1-3 alkylene group; R1 is selected from hydrogen, C1-4 hydrocarbyl and hydroxy-C2-4 hydrocarbyl; R2, R3 and R4 are the same or different and each is selected from hydrogen, fluorine, chlorine and methyl; Ar1 is an optionally substituted monocyclic 5 or 6-membered aryl or heteroaryl ring containing 0, 1 or 2 heteroatom ring members selected from O, N and S, or a naphthyl ring and Ar2 is an optionally substituted monocyclic 5 or 6-membered heteroaryl ring containing 1, 2 or 3 heteroatom ring members selected from O, N and S.The compounds of formula (1) are inhibitors of p70S6 kinase and are useful in the treatment of proliferative diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.