Process for the preparation of 6-substituted-1-(2H)-isoquinolinones

US8716481B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Kai Rossen · Hanau, DE
• Hermut Wehlan · Frankfurt am Main, DE
• Oliver Plettenburg · Kelkheim, DE
• Volker Kraft · Frankfurt am Main, DE
• Guenter Billen · Frankfurt am Main, DE
• Simon Gessler · Mannheim, DE

Key dates

• Filing date: Jun 17, 2010
• Grant date: May 6, 2014
• Expiry date: Mar 10, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/46
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for making 6-substituted-1-(2H)-isoquinolinone derivatives of formula (I)wherein R1 and n are as described in the specification. The present invention further relates to novel intermediates which are used in the process according to the invention and to processes for preparing such intermediates.