Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid

US8716495B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• David Hook · Rheinfelden, CH
• Thomas Ruch · Frenkendorf, CH
• Bernhard Riss · Huningue, FR
• Bernhard Wietfeld · Weil am Rhein, DE
• Gottfried Sedelmeier · Schallstadt, DE
• Matthias Napp · Burgdorf, CH
• Markus Bänziger · Bubendorf, CH
• Steven Hawker · Royston, GB
• Lech Ciszewski · East Hanover, US
• Liladhar Murlidhar Waykole · East Hanover, US

Key dates

• Filing date: Dec 21, 2011
• Grant date: May 6, 2014
• Expiry date: Mar 7, 2032

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof,wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, particularly in the preparation of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.