Hydroxylated contrast enhancement agents

US8722020B2 · kind B2 · utility

Assignee

• General Electric Company · US

Inventors

• Brian James Grimmond · Clifton Park, US
• Michael James Rishel · Saratoga Springs, US
• Rong Zhang · Zhejiang, CN
• Jeannette Christine DePuy · Burnt Hills, US

Key dates

• Filing date: Nov 30, 2010
• Grant date: May 13, 2014
• Expiry date: Nov 9, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6596
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In one aspect, the present invention provides a contrast enhancement agent comprising an iron chelate having structure I and salts thereofwherein R1 is independently at each occurrence a hydroxy group, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3 hydroxyalkyl group; and wherein Q is one or more charge balancing counterions. Also provided are a metal chelating ligand having structure IX and medical formulations comprising the contrast enhancement agent I.