Use of compounds extracted from Momordica charantia L. in the manufacture of medicaments for prevention and treatment of diabetes and obesity

US8722634B2 · kind B2 · utility

Assignees

• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN
• The Garvan Institute of Medical Research, Australia · AU

Inventors

• Yang Ye · Nanjing, CN
• Minjia Tan · Shanghai, CN
• Changqiang Ke · Shanghai, CN
• Tong Chen · Shanghai, CN
• Xiqiang Li · Shanghai, CN
• Edward W. Kraegen · Sydney, AU
• Jiming Ye · Sydney, AU
• David E. James · Batavia, US
• Gregory Cooney · Sydney, AU

Key dates

• Filing date: Jan 14, 2009
• Grant date: May 13, 2014
• Expiry date: Jan 27, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation of medications for prevention and treatment of diabetes and obesity. The above cucurbitane triterpenoids may be acted as a glucose uptake stimulator, an agonist for the translocation of glucose transporter 4 (GLUT4) to the cell membrane, and an activator of adenosine monophosphate-activated protein kinase (AMPK). They may have potential for the prevention and treatment of diabetes and obesity.