Oligonucleotides which inhibit p53 induction in response to cellular stress
US8722641B2 · kind B2 · utility
1Cited by
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21Claims
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Key dates
| Filing date | Jan 28, 2011 |
| Grant date | May 13, 2014 |
| Priority date | — |
| Expiry date | Jan 28, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/351
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to novel oligonucleotides which comprise p53 5′-UTR sequence TCCCTGG (SEQ ID NO: 1) or the complementary p53 3′-UTR sequence CCAGGGA (SEQ ID NO: 2) and their use for such therapeutic applications as protection of normal tissues from the toxicities of chemical or radiation exposure; reducing tissue damage in hypoxia-reperfusion injury, neurodegenerative disorders, oxidative stress, injuries, hyperthermia; preventing aging; preservation of tissues and organs prior to transplanting, etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.