Alpha-chloro and alpha-bromo phosphonate analogs of lysophosphatidic acid and methods of making and using thereof

US8722649B2 · kind B2 · utility

Assignees

• University of Utah Research Foundation · US
• University of Tennessee Research Foundation · US

Inventors

• Glenn D. Prestwich · Eastsound, US
• Gabor Tigyi · Memphis, US
• Guowei Jiang · Springfield, US
• Guanghui Yang · Shanghai, CN
• Joanna Gajewiak · Salt Lake City, US
• Honglu Zhang · Guilderland, US
• Xiaoyu Xu · Los Angeles, US

Key dates

• Filing date: Jun 13, 2008
• Grant date: May 13, 2014
• Expiry date: Nov 8, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6552
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Described herein is the synthesis and pharmacology of a series of α-substituted methylene phosphonate analogs, in which the α-CH2 moiety is replaced with CHCl or CHBr.