Salts and crystalline forms of an apoptosis-inducing agent

US8722657B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Nathaniel Catron · Vernon Hills, US
• Shuang Chen · Gurnee, US
• Yuchuan Gong · Waukegan, US
• Geoff G. Zhang · Vernon Hills, US

Key dates

• Filing date: Nov 21, 2011
• Grant date: May 13, 2014
• Expiry date: Jan 29, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Salts and crystalline forms of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.