Production of tissue engineered digits and limbs

US8728463B2 · kind B2 · utility

Assignee

• Wake Forest University Health Sciences · US

Inventors

• Anthony Atala · Winston-Salem, US
• James J. Yoo · Winston-Salem, US
• Grace Lim · Winston-Salem, US
• Sang Jin Lee · Suneung-ri, KR

Key dates

• Filing date: Mar 10, 2006
• Grant date: May 20, 2014
• Expiry date: Mar 4, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.