Antigen-binding proteins comprising recombinant protein scaffolds

US8728479B2 · kind B2 · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• Mark I. Greene · Levittown, US
• Hongtao Zhang · Zhaocheng, CN
• Xiaomin Song · Beijing, CN
• Ramachandran Murali · Swarthmore, US
• Masahide Tone · Cambridge, GB

Key dates

• Filing date: Mar 31, 2010
• Grant date: May 20, 2014
• Expiry date: Aug 17, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are recombinant protein scaffolds and recombinant multifunctional protein scaffolds for use in producing antigen-binding proteins In addition, nucleic acids encoding such recombinant protein scaffolds, recombinant multifunctional protein scaffolds, and antigen-binding proteins are provided Vectors and cells useful for expression of the described proteins are also provided, as are methods of use.