Adjuvants for use in vaccination

US8728515B2 · kind B2 · utility

Assignees

• Bangor University · GB
• UNIVERSITEIT GENT · BE

Inventors

• Mark Stephen Baird · Blaenau Ffestiniog, GB
• Juma' a Raheem Najeem Al-Dulayymi · Blaenau Ffestiniog, GB
• Cornelia Theunissen · Blaenau Ffestiniog, GB
• Gani Koza · Blaenau Ffestiniog, GB
• Seppe Vander Beken · Evergem, BE
• Johan Grooten · Evergem, BE

Key dates

• Filing date: Apr 22, 2009
• Grant date: May 20, 2014
• Expiry date: Jan 23, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/55555
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula (I) for use as an adjuvant in vaccination; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R2, R3 and R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene or cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester, thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C—OR5; wherein R5 is alkyl or haloalkyl, and A is S, O or NR6, wherein R6 maybe H or 20 alkyl.