Display of disulfide linked dimeric proteins in filamentous phage
US8728985B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Nov 15, 2010 |
| Grant date | May 20, 2014 |
| Priority date | — |
| Expiry date | Nov 15, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/1037
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods are provided for the display of a complex homodimer protein on the surface of a bacteriophage particle and combinatorial synthetic libraries of such proteins displayed as a fusion polypeptide with filamentous phage pIX coat protein. Heterodimeric or more complex interchain bonded structure, such as disulfide-linked, multimeric proteins, may be displayed using the method of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.