Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors

US8729064B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Christopher Flores · Lansdale, US
• Marina Nelen · Spring House, US
• Erica Nulton · Spring House, US
• Stephen Prouty · Philadelphia, US
• Matthew Todd · Spring House, US
• Sui-Po Zhang · Yeadon, US

Key dates

• Filing date: Mar 19, 2013
• Grant date: May 20, 2014
• Expiry date: Mar 19, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for treating diseases, syndromes, conditions and disorders that are affected by the inhibition of MGL, including pain. Such compounds are represented by Formula (I) as follows: are defined herein.