Heteroaryl nitrile compounds useful as inhibitors of Cathepsin-S

US8729114B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Michael J. Burke · West Haven, US
• Derek Cogan · Sandy Hook, US
• Donghong Amy Gao · Hopewell Junction, US
• Alexander Heim-Riether · Ingelheim am Rhein, DE
• Eugene Richard Hickey · Danbury, US
• Matthew Russell Netherton · Danbury, US
• Philip Dean Ramsden · Cambridge, US
• David Charles Thompson · White Plains, US
• Zhaoming Xiong · Brookfield, US

Key dates

• Filing date: Mar 2, 2011
• Grant date: May 20, 2014
• Expiry date: Mar 2, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are Cathepsin-S reversible inhibitor compounds of the formula (I) which are useful in the treatment of autoimmune and other diseases. Also disclosed are pharmaceutical compositions containing the same, and methods of making and using the same.