Agomelatine hydrobromide hydrate and preparation thereof
US8729132B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Mar 17, 2011 |
| Grant date | May 20, 2014 |
| Priority date | — |
| Expiry date | Mar 17, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to an agomelatine hydrobromide hydrate of formula Iwherein X is Br, preparation and use thereof, and to pharmaceutical compositions containing it. The agomelatine hydrobromide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.