Aryl di-substituted propenone compounds

US8729134B2 · kind B2 · utility

Assignee

• Heartlink Limited · AU

Inventors

• Michael Ruane · Hopedale, US
• Tracey-Ann Dickens · Fremantle, AU

Key dates

• Filing date: Nov 13, 2009
• Grant date: May 20, 2014
• Expiry date: May 24, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C45/68
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I):wherein R1 and R4 are OR7, R2 and R3 are H or OR7, with the proviso that when R2 is OR7 then R3 is H, and when R3 is OR7 then R2 is H; R5 and R6 are independently H, OH, or OR7 with the proviso that when R5 is OH, R6 is not OH; R7 is alkyl, aryl or arylalkyl; the drawing “” represents either a single or a double bond; or pharmaceutically acceptable salt(s) or prodrug(s) thereof. These compounds are useful of treatment, prophylaxis, amelioration, or defense against and/or prevention of hormonal dependent conditions, cancer, and diseases and conditions associated with oxidant stress.