Patent · US Active

Aldehyde tags, uses thereof in site-specific protein modification

US8729232B2 · kind B2 · utility

13Cited by

5References

95Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Jason Rush · Redondo Beach, US
Carolyn R. Bertozzi · Berkeley, US

Key dates

Filing date	Mar 20, 2009
Grant date	May 20, 2014
Priority date	—
Expiry date	Jun 8, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/20
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.