Preparation of N-alkylated opiates by reductive amination
US8729266B2 · kind B2 · utility
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18References
18Claims
0Family size
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Key dates
| Filing date | Jun 16, 2008 |
| Grant date | May 20, 2014 |
| Priority date | — |
| Expiry date | Aug 13, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to the reduction of an N-imine moiety or a hemiaminal moiety of a morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.