Process for the preparation of tapentadol and intermediates thereof
US8729308B2 · kind B2 · utility
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27Claims
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Key dates
| Filing date | Nov 30, 2010 |
| Grant date | May 20, 2014 |
| Priority date | — |
| Expiry date | Nov 30, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention refers to a new process for the synthesis of tapentadol comprising the quantitative resolution of the racemic mixture (V) to obtain the stereoisomer of (S)-3-(dimethylamino)-2-methyl-1-(3-nitrophenyl)-propan-1-one (VII) according to the Scheme 2 belowusing the (2R,3R)—O,O′-dibenzoyltartaric chiral acid wherein said resolution is quantitative.The present invention also refers to some intermediate compounds of the new synthesis process of tapentadol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.