Osteoinductive demineralized cancellous bone

US8734525B2 · kind B2 · utility

Assignee

• Warsaw Orthopedic, Inc.

Inventors

• Keyvan Behnam · Simi Valley, US
• Nanette Forsyth · Bayville, US
• James Russell · Lexington, US
• John Winterbottom · Howell, US
• Todd M. Boyce · Aberdeen, US

Key dates

• Filing date: Jun 16, 2008
• Grant date: May 27, 2014
• Expiry date: May 29, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents.