Antagonists of ligands and uses thereof
US8734760B2 · kind B2 · utility
14Cited by
5References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 18, 2012 |
| Grant date | May 27, 2014 |
| Priority date | — |
| Expiry date | Dec 10, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/495
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides multivalent ligand binding agents (traps) for members of the TGF-β superfamily and polypeptide linkers and methods for making and using such constructs. The traps may be used as therapeutic or diagnostic (imaging or non-imaging) agents for diseases/disorders caused by over-production/activity of the target ligand. In an embodiment of the invention there is provided a multivalent binding agent with affinity for a member of the TGF-β superfamily, the agent having the general structure I:(<bd1>-linker1)k-[{<bd1>-linker2-<bd2>-linker3f-}n-(<bd3>)m-(linker4-<bd4>)d]h,where:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.