Multiparticle pharmaceutical dosage form containing a mucoadhesively formulated peptide or protein active substances method for producing said pharmaceutical dosage form

US8734849B2 · kind B2 · utility

Assignee

• Evonik Röhm GmbH · DE

Inventors

• Rosario Lizio · Dieburg, DE
• Hans-Ulrich Petereit · Darmstadt, DE
• Erna Roth · Darmstadt, DE
• Inès Andres · Varese, IT
• Michael Damm · Rödermark, DE

Key dates

• Filing date: Jul 15, 2004
• Grant date: May 27, 2014
• Expiry date: Nov 8, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to an oral, multiparticle pharmaceutical dosage form containing pellets, the size of which ranges from 50 to 2500 μm and which essentially consist of: a) an inner matrix layer containing an active substance which is a peptide or a protein, including the derivatives or conjugates thereof, and which is embedded in a matrix consisting of a polymer with mucoadhesive effect, and b) an outer film coating essentially consisting of an anionic polymer or copolymer, which can be optionally formulated with pharmaceutically conventional adjuvants, more particularly softening agents.