Patent · US Active

Melibiose operon expression system

US8735099B2 · kind B2 · utility

0Cited by

4References

16Claims

0Family size

Assignee

MORPHOSYS AG · DE

Inventors

Johann Brass · Ausserberg, CH
Joachim Klein · Hochspeyer, DE
Ralf Ostendorp · Munich, DE

Key dates

Filing date	Apr 27, 2011
Grant date	May 27, 2014
Priority date	—
Expiry date	Apr 27, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/00
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

New vectors expressible in a host comprising the promoter region of the melibiose operon operably linked to a transcriptional unit that includes nucleic acid sequence which is heterologous to the host. The expression of the nucleic acid sequence is controlled by the promoter region of the melibiose operon. The new vector can be used for the regulated heterologous expression of a nucleic acid sequence in a prokaryotic host. There is an isolated and purified nucleic acid sequence expressible in a host comprising the promoter region of the melibiose operon operably linked to a transcriptional unit that includes a nucleic acid sequence which is heterologous to the host. The expression of the nucleic acid sequence is controlled by the promoter region of the melibiose operon. A prokaryotic host is transformed with the vector or the isolated and purified nucleic acid sequence. There is a method for producing a polypeptide in a host using the vector.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.