Non-viral delivery of compounds to mitochondria
US8735341B2 · kind B2 · utility
2Cited by
3References
12Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Apr 8, 2011 |
| Grant date | May 27, 2014 |
| Priority date | — |
| Expiry date | May 23, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A conjugate comprises: (a) a mitochondrial membrane-permeant peptide; (b) an active agent or compound of interest such as a detectable group or mitochondrial protein or peptide; and (c) a mitochondrial targeting sequence linking said mitochondrial membrane-permeant peptide and said active mitochondrial protein or peptide. The targeting sequence is one which is cleaved within the mitochondrial matrix, and not cleaved within the cellular cytoplasm, of a target cell into which said compound is delivered. Methods of use of such compounds are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.