Nucleoside phosphoramidate prodrugs

US8735372B2 · kind B2 · utility

Assignee

• Gilead Pharmasset LLC · US

Inventors

• Jinfa Du · New Hope, US
• Dhanapalan Nagarathnam · Bethany, US
• Michael Joseph Sofia · Carmel, US
• Peiyuan Wang · San Mateo, US

Key dates

• Filing date: Oct 18, 2013
• Grant date: May 27, 2014
• Expiry date: Oct 18, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure:Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.