Relaxin polypeptides comprising non-naturally encoded amino acids

US8735539B2 · kind B2 · utility

Assignee

• Ambrx, Inc. · US

Inventors

• Vadim Kraynov · San Diego, US
• Nick Knudsen · San Diego, US
• Ahma Hewet · Chula Vista, US
• Kristine De Dios · San Diego, US
• Jason Pinkstaff · Novato, US
• Lorraine Sullivan · San Diego, US

Key dates

• Filing date: Aug 17, 2011
• Grant date: May 27, 2014
• Expiry date: Aug 17, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Modified relaxin polypeptides and their uses are provided. In one aspect, the disclosure provides a relaxin polypeptide comprising one or more non-naturally encoded amino acids. The polypeptide may be linked to a linker, polymer, or biologically active molecule. The serum half-life of the relaxin polypeptide may be enhanced relative to the unconjugated form. In another aspect, the disclosure provides methods of treating a patient having a disorder modulated by relaxin.