Fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies

US8741310B2 · kind B2 · utility

Assignees

• Children's Medical Center Corporation · US
• President and Fellows of Harvard College · US
• Howard Hughes Medical Institute · US

Inventors

• Bing Chen · Westwood, US
• Gary H. Frey · Nashua, US
• Stephen C. Harrison · Cambridge, US

Key dates

• Filing date: Aug 27, 2010
• Grant date: Jun 3, 2014
• Expiry date: Jan 17, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16134
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Isolated, antigenic polypeptides including a prehairpin intermediate conformation of gp41 and vectors encoding such polypeptides are provided. Antibodies that bind to a prehairpin intermediate conformation of gp41 and methods of making antibodies a that bind to prehairpin intermediate conformation of gp41 are also provided. Vaccines against a prehairpin intermediate conformation of gp41, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided. Methods of screening compounds that bind to an isolated, prehairpin intermediate conformation of gp41 are further provided.