Graft materials containing ECM components, and methods for their manufacture

US8741352B2 · kind B2 · utility

Assignee

• Cook Biotech Incorporated · US

Inventors

• Jason P. Hodde · West Lafayette, US
• David M.J. Ernst · Lafayette, US
• Lal Ninan · Santa Rosa, US
• Sherry L. Voytik-Harbin · Zionsville, US
• Nathan J. Hammond · Lansing, US

Key dates

• Filing date: Sep 7, 2007
• Grant date: Jun 3, 2014
• Expiry date: Sep 13, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibroblast Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa-containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.