Patent · US Active

Follistatin-like protein-1 as a biomarker for inflammatory disorders

US8741584B2 · kind B2 · utility

2Cited by

19References

11Claims

0Family size

Assignee

University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

Raphael Hirsch · Pittsburgh, US
David C. Wilson · Leyland, GB

Key dates

Filing date	Feb 4, 2013
Grant date	Jun 3, 2014
Priority date	—
Expiry date	Feb 4, 2033

Classification

Technology area (CPC G)Physics
CPC primaryG01N2800/56
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention relates to methods and compositions for diagnosis of inflammatory disorders, and in non-limiting embodiments, of inflammatory disorders associated with elevated interleukin-1β (“IL-1β”), based on increased levels of follistatin-like protein 1 (“FSTL-1”). In particular non-limiting embodiments, the invention further provides for methods of identifying subjects with systemic onset juvenile idiopathic arthritis (“SOJIA”) who are at increased risk for developing macrophage activation syndrome (“MAS”) comprising detecting, in said subjects, hyper-increased levels of FSTL-1. In additional non-limiting embodiments, the invention provides for methods of identifying subjects with Kawasaki disease who are at increased risk of developing aortic aneurysms comprising detecting, in said subjects, hyper-increased levels of FSTL-1.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.