Nucleic acid molecule encoding a specific IL-1R1 antibody
US8741604B2 · kind B2 · utility
14Cited by
37References
6Claims
0Family size
Assignee
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Key dates
| Filing date | Sep 14, 2012 |
| Grant date | Jun 3, 2014 |
| Priority date | — |
| Expiry date | Sep 14, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to binding members, especially antibody molecules, specific for interleukin 1 receptor 1 (IL-1R1). For example, isolated binding members specific for IL-1R1 which competes with IL-1 and IL-1Ra for binding to IL-1R1 and binds Il-1R1 with a KD of 10 pM or less when measured by Kinexa™. The binding members are useful for, inter alia, treatment of disorders mediated by IL-1R1 including rheumatoid arthritis, asthma and chronic obstructive pulmonary disease (COPD).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.