T cell receptor display
US8741814B2 · kind B2 · utility
4Cited by
0References
6Claims
0Family size
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Key dates
| Filing date | Oct 21, 2009 |
| Grant date | Jun 3, 2014 |
| Priority date | — |
| Expiry date | Jul 26, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B40/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.