Method for the solid phase-based production of phosphate-bridged nucleoside conjugates

US8742094B2 · kind B2 · utility

Assignee

• Universitaet Hamburg · DE

Inventors

• Chris Meier · Jork, DE
• Viktoria Caroline Tonn · Hamburg, DE

Key dates

• Filing date: May 6, 2010
• Grant date: Jun 3, 2014
• Expiry date: May 6, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/11
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a method for producing phosphate-bridged nucleoside conjugates. In the method, a cyclosaligenyl nucleotide is produced first, to which a linker is added, which is used to perform the immobilization on a solid phase. A subsequent reaction with corresponding nucleophiles results in the desired phosphate-bridged nucleoside conjugates, which can then again be cleaved from the solid phase-bound linker.