Cycloalkylamine substituted isoquinolone derivatives

US8742116B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Oliver Plettenburg · Kelkheim, DE
• Armin Hofmeister · Frankfurt, DE
• Katrin Lorenz · Frankfurt am Main, DE
• Joachim Brendel · Bad Vilbel, DE
• Matthias Löhn · Frankfurt am Main, DE
• John Weston · Frankfurt am Main, DE

Key dates

• Filing date: Jun 18, 2009
• Grant date: Jun 3, 2014
• Expiry date: Nov 7, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to 6-substituted isoquinolone derivatives of the formula (I)useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.