Methods of identifying a compound that increases or decreases the interaction of Hn-33 with synaptotagmin II
US8748106B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Apr 18, 2006 |
| Grant date | Jun 10, 2014 |
| Priority date | — |
| Expiry date | Apr 23, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This application is based, inter alia, on the discovery of a binding interaction between the Hn-33 hemagglutinin polypeptide of the type A Clostridium botulinum neurotoxin complex and synaptosomal proteins, including synaptotagmin II (Syt II). Methods of screening for compounds that modulate, e.g., increase or decrease, this interaction are provided. Also provided are compositions and methods for targeting compounds to neuronal and cancer cells by coupling the compounds to Hn-33 or biologically active Hn-33 variants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.