Ketoreductase polypeptides for the reduction of acetophenones
US8748143B2 · kind B2 · utility
32Cited by
29References
7Claims
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Key dates
| Filing date | Sep 13, 2008 |
| Grant date | Jun 10, 2014 |
| Priority date | — |
| Expiry date | Jun 27, 2031 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/52
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.