Use of targeted nitroxide agents in bone healing

US8748369B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Michael W. Epperly · Pittsburgh, US
• Abhay Sudhir Gokhale · Galena, US
• Joel S. Greenberger · Dorpsstraat, US
• Peter Wipf · Pittsburgh, US
• Julianne Glowacki · Brookline, US

Key dates

• Filing date: Jun 4, 2010
• Grant date: Jun 10, 2014
• Expiry date: Jun 4, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P19/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are compositions and related methods useful for accelerating bone healing and growth. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity.