Patent · US Active

Conformation-selective nucleic acid inhibitors of AMPA glutamate receptors

US8748407B2 · kind B2 · utility

0Cited by
5References
15Claims
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Assignee

Inventors

Key dates

Filing dateFeb 25, 2013
Grant dateJun 10, 2014
Priority date—
Expiry dateFeb 25, 2033

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N2333/70571
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

The present invention relates to novel nucleic acid ligands or aptamers that demonstrate potent and selective inhibition of the open-channel conformation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.