C-28 amines of C-3 modified betulinic acid derivatives as HIV maturation inhibitors
US8748415B2 · kind B2 · utility
8Cited by
4References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 27, 2012 |
| Grant date | Jun 10, 2014 |
| Priority date | — |
| Expiry date | Mar 11, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-28 amines of C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS. In particular, the following compounds are provided herein, including pharmaceutically acceptable salts thereof:a compound of formula Ia compound of formula IIand a compound of formula III
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.