Optimized fluorocarbon emulsions for blood substitutes and other therapeutic uses
US8748497B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 22, 2007 |
| Grant date | Jun 10, 2014 |
| Priority date | — |
| Expiry date | Apr 27, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P7/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to a stable fluorocarbon emulsion having a continuous aqueous phase and discontinuous fluorocarbon phase comprising two fluorocarbons and surprisingly demonstrates that perfluorodecyl bromide is as effective in stabilizing perfluorooctyl bromide emulsions of certain concentrations than much more highly concentrated perfluorooctyl bromide/perfluorodecyl bromide emulsions without the significant problems experienced in higher concentrated emulsions such as longer organ retention times, formation of PFDB crystals, larger emulsion particles, manufacturing problems and inability of repeat dosing inherent with higher concentrations of perfluorodecyl bromide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.