Process for the preparation of 4-{4[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate

US8748622B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Juergen Stiehl · Winsen (Aller), DE
• Werner Heilmann · Wuppertal, DE
• Michael Logers · Wuppertal, DE
• Joachim Rehse · Leichlingen, DE
• Michael Gottfried · Wuppertal, DE
• Saskia Wichmann · Berlin, DE

Key dates

• Filing date: Apr 8, 2011
• Grant date: Jun 10, 2014
• Expiry date: Apr 8, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate.