Method and apparatus for quantitative imaging of blood perfusion in living tissue
US8750586B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 4, 2010 |
| Grant date | Jun 10, 2014 |
| Priority date | — |
| Expiry date | Mar 15, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/0042
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Embodiments provide methods and systems for quantitative imaging of blood perfusion in living tissue. A method provides for obtaining an optical microangiography (OMAG) image of a sample, wherein the image has an OMAG background sample; digitally reconstructing a homogeneous ideal static background tissue; replacing the OMAG background sample with the digitally reconstructed homogeneous ideal static background tissue; correlating two or more neighboring A-lines with the digitally reconstructed homogeneous ideal static background tissue; and measuring a phase difference between the two or more neighboring A-lines to quantify blood perfusion in the sample. Methods using digital reconstruction to reduce random phase noise in phase-resolved Doppler OCT are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.