Imaging probes, methods of making imaging probes, and methods of imaging

US8753605B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Zhen Cheng · 红钢城街道, CN
• Sanjiv S. Gambhir · Portola Valley, US
• Zheng Miao · Union City, US
• Hongguang Liu · Daxi District, TW
• Gang Ren · Shanghai, CN

Key dates

• Filing date: Aug 30, 2011
• Grant date: Jun 17, 2014
• Expiry date: Jul 6, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/71
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of detecting the over-expression of epidermal growth factor receptor (EGFR) in a subject or sample, methods of diagnosing the presence of one or more angiogenesis related diseases or related biological events in a subject or sample, method of monitoring the progress of one or more angiogenesis related diseases or related biological events in a subject or sample, a 18F-FBEM-CYS-ZEGFR:1907 probe, compositions including a 18F-FBEM-CYS-ZEGFR:1907 probe, and pharmaceutical compositions including a 18F-FBEM-CYS-ZEGFR:1907 probe and the like.