Multi-layered gradient vaginal ring

US8753667B2 · kind B2 · utility

Assignee

• The Population Council, Inc. · US

Inventors

• Bruce Variano · White Plains, US
• Jeffrey Speck · North Haledon, US
• Maria Teresa Sallent · New York, US
• Simone Evans · Brooklyn, US

Key dates

• Filing date: Apr 7, 2010
• Grant date: Jun 17, 2014
• Expiry date: Apr 7, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Multi-layered vaginal rings 2 comprising silicone elastomers and pharmaceutically active ingredients are disclosed. The rings comprise a number of layers, at least one of which contains a pharmaceutically active ingredient, and each of which is a silicone elastomer. The multiple layers preferably are produced from these layers of different compositions, including an inner layer 4, a middle layer 5, and an outer layer 6. After extrusion and simultaneous curing, however, the ring 2 includes a contiguous body which comprises a continuous silicone body providing unimpeded diffusion of the pharmaceutically active ingredient from the inner layer (s) 4 to the outer layer (s) 6. Methods of producing these vaginal rings and of using them are also disclosed.