Liposome composition for delivery of a therapeutic agent to eyes
US8753673B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 23, 2006 |
| Grant date | Jun 17, 2014 |
| Priority date | — |
| Expiry date | May 20, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/724
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a liposome composition for delivering high pay-load of a therapeutic agent to neovascularization sites of the eyes in a patient in need thereof. The liposome composition for entrapping the therapeutic agent comprises a particle forming component composed of a variety of vesicle-forming lipids, and an agent-carrying component able to form a complex with the therapeutic agent via electrostatic charge-charge interaction or hydrophobic-hydrophobic interaction; wherein the liposome composition comprising the therapeutic agent has a mean particle diameter of about 30 to 200 nm and may accumulate at the neovascularization sites of the eyes 24 hours after the intravenous administration of the liposome composition comprising the therapeutic agent to the patient. A method for delivering the therapeutic agent to the eyes in a patient with this liposome composition is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.